Posts Tagged 'PTPN22'

Introducing My Lupus Research Project

My name is Ami Yamamoto, and I have the great opportunity of being one of the Lupus Foundation of Minnesota’s  Student Summer Fellows for 2013. This summer, I am studying under Erik Peterson, M.D., in the Department of Rheumatic and Autoimmune Diseases at the University of Minnesota–Twin Cities.

As I will write about in more detail in a later post, my project is to contribute to research on the gene PTPN22 which Dr. Peterson and his team thinks ...

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Local lupus study recruiting participants

SLE is an autoimmune disease capable of causing severe tissue damage in many organs. The cause of SLE is unknown, but recent research has identified infection-fighting proteins called interferons (or IFNs) which are made and released by host cells in response to the presence of pathogens such as viruses, bacteria, parasites or tumor cells. IFNs allow for communication between cells to trigger the protective defenses of the immune system that eradicate pathogens or tumors.

In this ...

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Come hell or high water

“I recommend that you take the medication each day, come hell or high water.”

I sometimes use this cliché’ phrase as I counsel patients suffering with Systemic Lupus Erythematosus (SLE). Clinical research shows that diligence and persistence in use of immune system-modulating drugs is important for optimal disease control for many people with SLE. Some drugs need to be taken day in and day out, for months or years, to be most effective. Repeated clinic visits, blood monitoring requirements, pharmacy charges, ...

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“I now feel like a real scientist …”

Over the past two weeks, I have performed pilot experiments to finalize the design of my final project. One of these pilots compared an infected wild type model with an uninfected one; wild type means that the model has not been genetically modified in any way.

A day after infection, I examined spleen for the presence of certain dendritic cell variants. Dendritic cells are one of many types of white blood cells, and some of their subsets are found in greater ...

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What my lupus research project is

Now that we’ve gone through the introductions, here’s a little bit about the project I’m working on (I promise it will be understandable!). I am examining the role of a lupus-associated gene, called PTPN22, in response to viral infection. Many people with lupus, and other autoimmune diseases such as rheumatoid arthritis, have a mutation in this gene and produce a mutated protein. This protein’s mutation is in the form of a substituted amino acid at position 620.

What does that mean? ...

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